Skip to content

Are Collagen Peptides Always Hydrolyzed? A Deep Dive

4 min read

According to scientific research, native collagen molecules are too large to be effectively absorbed by the human body. This critical fact explains why the vast majority of collagen products are processed. To be called 'collagen peptides', the substance must be broken down into smaller fragments via a process known as hydrolysis.

Quick Summary

Collagen peptides are the result of processing native collagen through hydrolysis to improve digestibility and absorption. While the terms are often used interchangeably, all collagen peptides have undergone this breakdown process, distinguishing them from larger, non-hydrolyzed collagen molecules like gelatin.

Key Points

  • All Supplemental Peptides are Hydrolyzed: Any product labeled as 'collagen peptides' has undergone hydrolysis, a process that breaks down large collagen molecules into smaller, absorbable fragments.

  • Hydrolysis Enhances Absorption: The primary purpose of hydrolysis is to increase the bioavailability of collagen, making it easier for the body to digest and utilize the protein.

  • Collagen Peptides vs. Gelatin: Unlike gelatin, which is only partially hydrolyzed and forms a gel, collagen peptides are fully hydrolyzed, allowing them to dissolve completely in liquids.

  • Manufacturing Process is Key: The conversion of native collagen to peptides involves several steps, including sourcing, pre-treatment, extraction, and finally, hydrolysis using enzymes or acids.

  • Source Doesn't Change the Process: Whether sourced from bovine, marine, or poultry, the raw collagen must be hydrolyzed to create the peptides found in supplements.

  • Degree of Hydrolysis Matters: The extent of the hydrolysis process determines the molecular weight of the peptides, which can be tailored for different products and absorption rates.

In This Article

Understanding the Truth About Collagen Peptides

When shopping for supplements, it is common to see labels that use the terms 'collagen peptides' and 'hydrolyzed collagen' interchangeably. The short answer to the question, "Are collagen peptides always hydrolyzed?" is a resounding yes. The hydrolysis process is what creates the small, bioavailable peptides from the large, native collagen protein. This is a fundamental aspect of how these popular supplements are manufactured and why they are so easily dissolved and digested by the body.

The Science Behind Hydrolysis

Collagen is the most abundant protein in the body, but its native form is a large, triple-helix structure that is difficult for the body to absorb directly. The purpose of hydrolysis is to break these long protein chains down into smaller fragments, known as peptides. This process is typically achieved using water and specific enzymes (enzymatic hydrolysis), though chemical methods can also be used. The result is a powder that can be easily mixed into hot or cold beverages and digested quickly. Without this crucial step, the protein would remain in a state that offers significantly less efficient absorption.

Hydrolyzed vs. Non-Hydrolyzed Collagen

To better understand why hydrolysis is essential for supplemental collagen peptides, it's helpful to compare them with non-hydrolyzed forms. The most common example of a partially hydrolyzed or non-hydrolyzed product is gelatin. Gelatin, which also comes from animal collagen, is only partially broken down, resulting in a product that forms a gel in cold liquids and is harder to digest. In contrast, fully hydrolyzed collagen peptides dissolve completely in liquids, making them far more versatile for use in supplements. Your body can process un-hydrolyzed collagen from food sources like bone broth, but the manufacturing process for peptides pre-digests the protein, ensuring maximum efficiency.

What the Degree of Hydrolysis Means

The level of hydrolysis has a significant impact on the final product. Manufacturers can control the extent to which the collagen is broken down, which influences its molecular weight. For instance, some "nano-hydrolyzed" products are processed further to achieve an even lower molecular weight, promising faster absorption. Most standard collagen peptide products aim for an average molecular weight that is significantly lower than native collagen, ensuring excellent solubility and bioavailability. This precision allows companies to tailor products for specific health goals, from improving skin hydration to supporting joint health.

Different Sources, Same Process

Collagen peptides can be sourced from various animals, including bovine (cows), marine (fish), and poultry (chicken). Despite their different origins and dominant collagen types (e.g., Type I in marine, Type I and III in bovine), they all undergo the same hydrolysis process to be converted into peptides for supplementation. The source determines the specific amino acid profile and types of collagen present, but the fundamental manufacturing step is identical across the board.

The Manufacturing Journey of Collagen Peptides

The journey from raw material to a fine, soluble powder involves several key stages:

  • Sourcing: Raw animal materials, such as hides, bones, and scales, are sourced. The origin can influence the types of collagen extracted.
  • Pre-treatment: Materials are cleaned, degreased, and demineralized to remove impurities and prepare them for processing.
  • Extraction: Collagen is extracted by boiling the prepared materials in water.
  • Hydrolysis: The extracted collagen is then treated with enzymes or acids to break it into smaller peptides. This is the crucial step that creates the peptides.
  • Filtration & Purification: The peptide solution is filtered to remove any remaining large particles or impurities, and then deionized to enhance purity.
  • Drying: The purified solution is dried, typically using a spray-drying technique, to create the final powder form.

Hydrolyzed vs. Non-Hydrolyzed Collagen Properties

Feature Hydrolyzed Collagen (Peptides) Non-Hydrolyzed Collagen (Gelatin)
Molecular Size Small peptides (low molecular weight) Large protein chains (high molecular weight)
Absorption Rate High, easily absorbed Lower, requires more digestion
Digestibility Very easy on the stomach Can be harder to digest for some
Mixability Dissolves completely in cold or hot liquids Forms a gel in cold liquids
Appearance Fine, odorless powder Forms a viscous, sometimes thick liquid
Primary Use Dietary supplement for skin, joints, etc. Gelling agent in food and cooking

Conclusion

In conclusion, the terminology might be confusing, but the scientific fact is clear: all products marketed as "collagen peptides" have been hydrolyzed to some degree. This manufacturing step is not optional but is integral to creating a product that is highly bioavailable and easily absorbed by the body. The smaller peptide fragments are designed for maximum efficiency, making supplemental collagen a much more effective option than relying on non-hydrolyzed food sources alone for targeted benefits. So, when you choose a collagen peptide supplement, you are, by definition, choosing a hydrolyzed product. The only remaining decision is the source and type that best suits your health goals. For further reading on collagen and supplementation, consider consulting resources like the National Institutes of Health.

Frequently Asked Questions

There is no difference; the terms are synonymous. 'Collagen peptides' describes the final product (small peptide chains), while 'hydrolyzed collagen' refers to the process (hydrolysis) used to create it.

No, not all collagen is hydrolyzed. Collagen found naturally in food sources like bone broth and skin is non-hydrolyzed. Only collagen manufactured for supplements as peptides undergoes hydrolysis for better absorption.

Hydrolysis is necessary because native collagen molecules are too large to be effectively absorbed by the body. Breaking them into smaller peptides makes the protein highly bioavailable, ensuring it can be used efficiently.

Your body can digest and absorb collagen from foods, but not as efficiently as pre-digested collagen peptides. Supplemental peptides offer a more direct and readily available source of the protein for your body.

The source (e.g., bovine, marine) does not change the fundamental hydrolysis process. It does, however, determine the type(s) of collagen and the specific amino acid profile in the final product.

If a product is labeled 'collagen peptides', 'hydrolyzed collagen', or 'collagen hydrolysate', it has undergone the hydrolysis process. These terms are indicators of a readily absorbable, processed product.

Gelatin is partially hydrolyzed collagen, not fully. This partial breakdown is why it has gelling properties, and it is less bioavailable and effective for targeted supplementation than fully hydrolyzed peptides.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.