Can Collagen and MSM Be Taken Together? The Synergy Explained

December 6, 2025 •

4 min read

According to a study published in the Journal of Functional Foods, the combination of hydrolyzed collagen and MSM significantly improved skin thickness and roughness more than collagen alone. This research confirms that not only can collagen and MSM be taken together, but they also offer powerful synergistic benefits for both joint and skin health.

Quick Summary

This article explores the safety and enhanced benefits of combining collagen and MSM supplements. It details their complementary mechanisms of action for improving joint function, reducing inflammation, and boosting skin elasticity, supported by research findings and practical usage tips.

Key Points

Synergistic Effect: Combining collagen and MSM produces a more potent effect on skin and joint health than taking either supplement alone.
MSM Enhances Collagen: MSM provides the organic sulfur crucial for synthesizing new collagen, making the collagen peptides you consume more effective.
Reduces Inflammation: MSM's powerful anti-inflammatory properties can offer quicker relief from joint pain and muscle soreness.
Improves Skin Appearance: Studies show the combination can significantly improve skin thickness, roughness, and hydration.
Generally Safe: Both supplements are considered safe for most people, but starting with a lower dose is recommended to assess tolerance.
Pair with Vitamin C: Taking collagen with Vitamin C can optimize absorption and boost collagen fiber synthesis.
Check Product Quality: Choose high-quality supplements that are transparent about sourcing and third-party tested for purity.
Consult a Doctor: Always talk to a healthcare provider before starting a new supplement, especially if you have existing health conditions.

Why Combining Collagen and MSM Offers Synergistic Benefits

While both collagen and Methylsulfonylmethane (MSM) are popular supplements with independent benefits, combining them can create a powerful synergy that amplifies their effects on connective tissues, skin, and joints. Collagen is the body's primary structural protein, providing the building blocks for cartilage, skin, tendons, and ligaments. However, MSM plays a critical, complementary role by supplying the organic sulfur necessary for the synthesis of new, healthy collagen and keratin. This teamwork approach offers a more comprehensive strategy for supporting the body's natural regenerative processes.

The Role of Collagen

Collagen is the most abundant protein in the human body, but its natural production declines with age. This decrease leads to common signs of aging, such as reduced skin elasticity, wrinkles, and joint pain. By supplementing with hydrolyzed collagen, the body receives the amino acid peptides needed to replenish and rebuild these tissues. The most common types of collagen for supplementation are:

Type I: Found in skin, bones, and tendons, providing structure and firmness.
Type II: The primary collagen in cartilage, crucial for joint health.

The Role of MSM

MSM is an organic sulfur compound that acts as a powerful anti-inflammatory agent. It is essential for numerous biological processes and plays a key role in supporting the production of collagen and keratin. Its anti-inflammatory effects can provide quicker relief from pain and stiffness compared to the slower, long-term structural rebuilding provided by collagen. MSM's benefits include:

Reducing inflammation and oxidative stress.
Alleviating joint pain and muscle soreness.
Improving skin hydration, texture, and thickness.
Strengthening hair and nails by supporting keratin production.

A Comparison of Collagen and MSM's Mechanisms

To better understand their combined power, here's a breakdown of how these two supplements work individually and together:


Feature	Collagen	MSM (Methylsulfonylmethane)
Primary Role	Provides structural building blocks (amino acids) for connective tissues.	Supplies sulfur, a key component for synthesizing new collagen and keratin.
Primary Action	Long-term tissue regeneration and repair.	Reduces inflammation and pain; supports tissue quality.
Symptom Relief	Slower, restorative effect on pain from joint degeneration.	Quicker anti-inflammatory effect, reducing pain and stiffness.
Targeted Area	Primarily cartilage, bones, tendons, ligaments, and skin.	Supports collagen synthesis throughout the body, with a noticeable impact on skin and joints.
Synergy	Offers the raw materials needed for structural repair.	Creates an optimal environment for collagen to be effectively produced and utilized.

Evidence for the Combination's Efficacy

Several studies support the notion that the combination of collagen and MSM is more effective than either supplement alone. For example, a randomized, placebo-controlled study found that participants taking a combination of hydrolyzed fish collagen and MSM experienced superior improvements in skin thickness and roughness compared to those taking collagen only. The study also noted that adding MSM doubled the improvement in skin roughness over the 12-week period. For joint health, other studies have shown that combining MSM with collagen, glucosamine, and chondroitin is an effective and safe nutritional approach for managing symptoms of knee osteoarthritis.

How to Take Collagen and MSM Together

Optimal Timing: The best time to take these supplements is often debated. Some experts suggest taking collagen in the morning or before bed to align with the body's natural regenerative cycles, while MSM can be taken anytime. Taking them both at the same time is also completely safe and effective.
Forms of Supplementation: Both are available in various forms, including powders, capsules, and liquids. Powders can be easily mixed into smoothies, coffee, or juice.
Incorporate with Vitamin C: For maximum absorption and efficacy, it is highly recommended to take collagen with Vitamin C, as it is a crucial cofactor in collagen synthesis.
Hydration is Key: Ensure you are drinking plenty of water, as proper hydration is essential for the effectiveness of both supplements.

Potential Side Effects and Considerations

While the combination is generally well-tolerated, some individuals may experience mild side effects, such as digestive issues like bloating, diarrhea, or an upset stomach. It is always best to start with a lower dose to see how your body reacts and to consult with a healthcare provider before beginning any new supplement regimen, especially if you have pre-existing health conditions, are pregnant, or are taking other medications.

Finding the Right Supplements

When choosing a product, look for high-quality, reputable brands that offer transparent sourcing and are third-party tested for purity and potency. For joint health, specifically, type II collagen is particularly beneficial as it is the main component of cartilage. For overall skin, hair, and nail health, types I and III collagen are typically recommended. Many products now offer a combined formulation, simplifying the supplementation process.

Conclusion

Yes, you can confidently take collagen and MSM together, and doing so often leads to better results than taking either supplement individually. Their synergistic relationship provides a comprehensive approach to supporting joint health, reducing inflammation, and improving the health and appearance of your skin, hair, and nails. MSM helps create the optimal environment for collagen synthesis, while collagen provides the necessary building blocks for tissue repair. With consistent use and by following best practices, this powerful duo can be a significant boost to your overall wellness routine.

The Final Word on Combining Collagen and MSM

The evidence is clear: the combination of collagen and MSM is not just safe, but it's also highly effective. Whether you're an athlete looking for faster recovery, an individual managing age-related joint stiffness, or someone aiming for healthier, more radiant skin, this complementary pairing is a strategic choice for comprehensive wellness. By providing both the foundational material and the vital compounds for building and maintenance, you're giving your body a potent one-two punch for health and rejuvenation.

Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a healthcare professional before starting any new supplement regimen.

Frequently Asked Questions

You can take collagen and MSM together in a single combined product or as separate supplements. Powder forms are popular and can be mixed into drinks like smoothies or coffee. Some suggest taking collagen in the morning or at night for regeneration, while MSM can be taken anytime, but consistency is most important.

Results vary depending on individual factors, but many people report noticeable improvements in skin and joint comfort within a few weeks to a few months of consistent use. MSM often provides faster relief from inflammation, while collagen's regenerative effects take longer to become apparent.

Combining collagen and MSM offers numerous benefits, including enhanced joint pain relief, reduced inflammation, improved skin elasticity and hydration, stronger hair and nails, and faster muscle recovery after exercise.

Both are generally well-tolerated, but some individuals may experience mild digestive side effects, such as bloating, stomach upset, or diarrhea. It's always best to start with a low dose and consult a doctor, especially if you have other health issues.

For targeting joint health and cartilage, Type II collagen is the most relevant type to combine with MSM, as it is the primary component of cartilage. However, many people benefit from a multi-collagen product containing Types I, II, and III for a broader spectrum of benefits.

MSM doesn't directly aid in collagen absorption but enhances its effectiveness. It provides the essential sulfur needed for the synthesis of new collagen and keratin, creating a more favorable environment for the body to utilize the amino acids from collagen supplements.

Yes, collagen and MSM can often be safely taken with other supplements. Vitamin C is highly recommended as it aids in collagen synthesis. Some formulas also combine them with glucosamine and chondroitin for enhanced joint support. Consult a healthcare provider for personalized advice.

Yes, research supports the synergistic effects of combining collagen and MSM. A 12-week study found that a combination of hydrolyzed fish collagen and MSM resulted in greater improvements in skin thickness and roughness compared to collagen alone. Other studies have noted effectiveness for knee osteoarthritis as well.