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Can Eating Once a Day Lower Cholesterol? What the Science Says

4 min read

While proponents of one-meal-a-day (OMAD) diets claim numerous health benefits, several scientific studies indicate that eating once a day may actually increase cholesterol levels, specifically LDL or “bad” cholesterol. Understanding the full picture is crucial for anyone considering this extreme dietary approach.

Quick Summary

Eating one meal a day may surprisingly increase cholesterol and blood pressure, despite potential for weight loss. Healthier, balanced nutrition is a more proven method for improving heart health markers.

Key Points

  • OMAD May Increase Cholesterol: Studies show that eating once a day (OMAD) can surprisingly increase total and LDL ('bad') cholesterol levels in healthy adults, not decrease them.

  • Metabolic Stress is a Factor: The extreme fasting of OMAD can induce metabolic stress and increase cortisol, which may contribute to unfavorable changes in lipid profiles.

  • Nutritional Deficiencies are a Risk: Meeting all nutrient requirements in a single meal is extremely difficult and can lead to deficiencies, negatively impacting overall health.

  • Healthier Methods are More Reliable: A balanced diet rich in soluble fiber and healthy fats, along with regular exercise, is a proven, safer, and more effective way to manage and lower cholesterol levels.

  • Not Suitable for Everyone: OMAD is not recommended for individuals with diabetes, eating disorders, or those who are pregnant or breastfeeding due to significant health risks.

  • OMAD is Less Sustainable: The extreme nature of the diet and intense hunger often lead to high dropout rates and a risk of rebound weight gain.

In This Article

The Surprising Link Between OMAD and Higher Cholesterol

Many people are drawn to the one-meal-a-day (OMAD) diet for its simplicity and potential for rapid weight loss. However, research into its effect on heart health reveals a complex and often contradictory picture. Far from being a reliable method to lower cholesterol, some studies suggest that OMAD can lead to increased total and LDL cholesterol levels. This effect is particularly pronounced when comparing OMAD to more moderate eating patterns or other forms of intermittent fasting.

One controlled trial involving healthy, normal-weight adults who switched to a one-meal-per-day diet showed significant increases in their total and LDL cholesterol levels over an eight-week period. This occurred even as participants experienced a decrease in body weight and fat mass. The rise in cholesterol, alongside elevated blood pressure and cortisol levels, suggests that the extreme caloric restriction and subsequent long fasting period place significant stress on the body's metabolic system.

Why Might OMAD Raise Cholesterol?

The mechanism behind OMAD's negative impact on cholesterol is not fully understood, but several factors are believed to contribute:

  • Metabolic Stress: The body is forced to undergo a metabolic switch, relying on stored fat for energy during the extended fasting period. While some forms of fasting can improve metabolic markers, the extreme nature of OMAD may trigger a stress response, leading to adverse changes in lipid profiles.
  • Nutrient-Poor Choices: With only one meal a day, there is a risk of overconsuming high-calorie, nutrient-poor, or highly processed foods to feel satiated. If the single meal is high in saturated or trans fats, it can directly contribute to higher LDL cholesterol.
  • Calorie Restriction vs. Meal Timing: While intermittent fasting in general, when done correctly, can sometimes lead to improved lipid profiles, the intensity of the OMAD protocol appears to negate these benefits for cholesterol in many cases. The benefits often seen with less restrictive fasting might be tied more to overall calorie reduction and healthier food choices, rather than the specific timing.
  • Lack of Sustainability: OMAD is difficult to sustain long-term due to intense hunger, energy fluctuations, and the high risk of nutritional deficiencies. This can lead to a rebound effect where individuals revert to unhealthy eating habits, worsening their cholesterol levels and overall health.

Healthier, Proven Strategies for Cholesterol Management

If your goal is to lower cholesterol and improve heart health, relying on an extreme diet like OMAD is not the most effective or safest path. The following evidence-based strategies are much more reliable:

  • Increase Soluble Fiber: This type of fiber, found in oats, barley, apples, and beans, can help lower LDL cholesterol by binding to cholesterol and removing it from the body.
  • Eat Healthy Fats: Incorporate unsaturated fats from sources like nuts (almonds, walnuts), seeds, avocados, and olive oil. These help lower LDL and increase HDL ("good") cholesterol.
  • Regular Exercise: Aim for at least 150 minutes of moderate aerobic activity per week. Exercise can help raise HDL levels and is a cornerstone of heart health.
  • Limit Saturated and Trans Fats: Minimize consumption of fatty meats, butter, hard cheese, and processed foods containing partially hydrogenated oils to directly reduce LDL cholesterol intake.
  • Consume Omega-3s: Foods rich in omega-3 fatty acids, such as fatty fish (salmon, mackerel) and flaxseed, can help lower triglycerides and have heart-protective effects.

Comparing OMAD to Healthier Dietary Approaches

To highlight the difference, here is a comparison table outlining OMAD versus a balanced, heart-healthy diet for managing cholesterol.

Feature One-Meal-a-Day (OMAD) Balanced, Heart-Healthy Diet
Effect on Cholesterol May increase total and LDL cholesterol; inconsistent results. Consistently shown to reduce total and LDL cholesterol.
Meal Frequency One large meal in a limited window, typically 1 hour. Multiple, balanced meals throughout the day.
Metabolic Impact Can cause metabolic stress and higher cortisol levels. Promotes steady energy levels and metabolic health.
Nutritional Adequacy High risk of nutrient deficiencies; difficult to get all vitamins and minerals. Easily provides all necessary nutrients and fiber.
Satiety and Hunger Often results in extreme hunger and cravings. Promotes feeling full and satisfied, minimizing binge risks.
Sustainability Low long-term sustainability due to difficulty and side effects. Highly sustainable and recommended by health professionals.

Who Should Avoid the OMAD Diet?

Because of the risks involved, health experts advise several groups of people to avoid the OMAD diet.

  • Individuals with a history of eating disorders.
  • People with diabetes or hypoglycemia, as it can cause dangerous blood sugar fluctuations.
  • Pregnant or breastfeeding women, who have increased nutritional needs.
  • Children and teenagers, who require consistent fuel for growth and development.
  • Older adults, who may have specific nutritional requirements and health conditions.
  • Anyone taking medications that require regular food intake.

A Conclusive Look at the Evidence

The belief that eating once a day is a guaranteed way to lower cholesterol is, for many, a misconception not supported by scientific evidence. While it may induce weight loss, the mechanism appears to put the body under stress that can lead to an unfavorable lipid profile, potentially increasing heart disease risk. The composition of the single meal is paramount, but even healthy participants have shown negative cholesterol impacts. For individuals seeking to manage or lower their cholesterol, a balanced, fiber-rich diet combined with regular exercise is a safer, more effective, and sustainable strategy recommended by health professionals. As with any significant dietary change, it is crucial to consult a healthcare provider to ensure it aligns with your overall health needs.

Frequently Asked Questions

For many, eating once a day is not beneficial and can be bad for heart health. Studies have shown it can lead to increased total cholesterol, LDL cholesterol, and blood pressure, which are all risk factors for cardiovascular disease.

Your cholesterol may have increased due to the metabolic stress placed on your body by the extreme fasting, even if you lost weight. The composition of your single meal, if high in unhealthy fats, can also contribute to the rise in LDL cholesterol.

Not necessarily. Some forms of intermittent fasting show promise for improving lipid profiles, especially when combined with healthier eating overall. However, the extreme 23:1 fasting of the OMAD diet is where the most significant negative cholesterol effects have been observed.

A heart-healthy diet rich in soluble fiber, nuts, seeds, and omega-3 fatty acids is considered the best dietary approach for lowering cholesterol. Limiting saturated and trans fats is also critical.

While weight loss is generally beneficial, the metabolic stress from OMAD can cause an increase in LDL cholesterol and blood pressure, potentially negating some heart health benefits. The net effect on heart health is not consistently positive, making it a risky strategy.

Safer alternatives include practicing less extreme forms of intermittent fasting (like 16:8), following a Mediterranean-style diet, and focusing on overall balanced nutrition with regular exercise.

No, OMAD is generally not sustainable long-term. Its extreme nature often leads to intense hunger, nutrient deficiencies, and is associated with a high dropout rate, making it an unreliable method for sustained health improvements.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.