Category: Genetic health

The MTHFR C677T gene mutation, which is present in a significant portion of the population, impairs the body's ability to convert synthetic folic acid into its active form. Navigating which foods to avoid if you have this MTHFR C677T variation is a critical step in managing your health and supporting proper methylation.

An extremely rare autosomal recessive metabolic disorder, dimethylglycine dehydrogenase (DMGDH) deficiency, is the true medical condition behind what is colloquially known as dimethylglycine deficiency. The key characteristic is not a simple nutritional shortfall, but a genetic inability to properly process the amino acid derivative N,N-dimethylglycine (DMG), leading to specific, identifiable symptoms.

The MAOA gene, sometimes called the 'warrior gene,' is responsible for producing the enzyme monoamine oxidase A, which regulates key neurotransmitters like serotonin, dopamine, and norepinephrine. Variants in this gene can impact how these chemicals are metabolized, influencing mood, stress response, and behavior. Targeted nutritional support can be essential for those with specific MAOA gene variants to maintain proper balance.

The first successful dietary treatment for phenylketonuria (PKU) was developed in 1951, forever changing the prognosis for children born with this rare genetic disorder. The classical PKU diet is a strict, low-phenylalanine regimen that, when implemented shortly after birth, is crucial for preventing severe intellectual disability and other neurological complications. It remains the foundation of therapy for many individuals with PKU.

According to research, up to 60% of people have a genetic variation that may impair their body's ability to convert synthetic folic acid into its active form. This makes understanding who needs L-methylfolate, the active form of folate, a crucial part of personalized health management. For many, simply consuming folic acid is enough, but certain genetic and health factors can necessitate a direct supplement of L-methylfolate to ensure adequate folate levels.

While the internet buzz around 'methylated' vitamins is widespread, the claim that every B vitamin needs this conversion is a myth. Do all B vitamins need to be methylated? The answer is no; the need for a pre-methylated form is specific to only two B vitamins and for certain individuals.

Affecting roughly 1 in 100,000 newborns, primary carnitine deficiency stems from a genetic transport defect, setting it apart from secondary carnitine deficiency, which is caused by other medical issues, medications, or malnutrition.

Research indicates that micronutrient deficiencies can be a major cause of DNA damage, making the body's repair systems less efficient. Fortunately, certain foods can support your body's natural mechanisms for cellular repair, helping answer the question of what foods are good for restoring DNA.

An estimated 40-60% of people have genetic variations in the MTHFR gene, which affects the body's ability to properly process folic acid and some forms of B12. This is a primary reason why a specialized B complex without B12 and folate is necessary for some individuals.

Genetic variations in the MTHFR gene are common, with up to 40% of the US population having at least one variant that can impact the body's ability to process folate. Understanding what supplements should you avoid with MTHFR is a key step for managing health, as certain forms can be ineffective or even counterproductive for those with impaired methylation.