Category: Nutritional anemia

Megaloblastic anemia is most often caused by a deficiency of vitamin B12 (cobalamin) or folate (vitamin B9), both of which are crucial for healthy red blood cell production. It is a condition characterized by impaired DNA synthesis, leading to the formation of abnormally large, immature red blood cells.

According to the National Institutes of Health, a deficiency in vitamin B6 (pyridoxine) can significantly impair heme synthesis and lead to a form of sideroblastic anemia, a rare blood disorder. This condition results from the bone marrow's inability to properly utilize iron to form healthy red blood cells, causing iron to accumulate abnormally.