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Dietary Management: What to Eat When You Have Diarrhea on Immunotherapy?

4 min read

Diarrhea is a common and potentially serious side effect of cancer immunotherapy, with some studies indicating that immune checkpoint inhibitor-induced colitis can affect a significant percentage of patients. Knowing what to eat when you have diarrhea on immunotherapy is crucial for managing symptoms, preventing dehydration, and maintaining overall nutritional status during treatment. This guide offers practical dietary strategies to help patients cope with gastrointestinal distress and support their recovery.

Quick Summary

This guide provides practical dietary strategies for managing diarrhea caused by immunotherapy, focusing on hydration and electrolyte replenishment. It details beneficial low-fiber foods, essential foods to avoid, and addresses potential issues like temporary lactose intolerance to help patients maintain nutrition and comfort during treatment.

Key Points

  • Prioritize Hydration: Dehydration is a significant risk with diarrhea, so focus on drinking plenty of clear fluids, water, broth, and oral rehydration solutions to replace lost fluids and electrolytes.

  • Adopt the BRAT Diet for Acute Relief: For short-term diarrhea, eating bland, low-fiber foods like bananas, rice, applesauce, and toast can help solidify stools and soothe the digestive system.

  • Introduce Low-Fiber, Lean Proteins Gradually: As symptoms improve, incorporate easy-to-digest proteins like baked chicken or fish and well-cooked, peeled vegetables to maintain nutrition.

  • Avoid Trigger Foods: Steer clear of high-fiber foods, greasy or fatty items, spicy foods, caffeine, and alcohol, as these can irritate the bowel and worsen diarrhea.

  • Monitor for Lactose Intolerance: Immunotherapy can cause temporary lactose intolerance. Limiting or avoiding milk and soft dairy products may help reduce symptoms.

  • Eat Small, Frequent Meals: Instead of three large meals, eat smaller portions throughout the day to make digestion easier on a sensitive stomach.

  • Consult Your Care Team: Always talk to your oncologist or a registered dietitian before making dietary changes during immunotherapy to ensure it's safe and effective for your specific treatment.

In This Article

Hydration and Electrolyte Balance

The single most critical component of managing diarrhea is preventing dehydration. Diarrhea causes the body to lose significant fluids and essential electrolytes, such as sodium and potassium. Replenishing these is vital for your health, energy levels, and cellular function.

Essential fluids and how to consume them

  • Water: Sip plain, room-temperature water throughout the day. Avoid large quantities at once, which can overwhelm the digestive system.
  • Broth: Clear broths, like chicken or vegetable, are excellent for replacing lost sodium and fluids. They are easy to digest and soothing.
  • Oral rehydration solutions: Electrolyte drinks such as Pedialyte or sports drinks (e.g., Gatorade) are formulated to restore electrolytes. Diluting them with water can make them easier on the stomach.
  • Fruit nectars: Choose clear, non-acidic juices like apple, peach, or pear nectar. Dilute them with water to make them less irritating to the gut.
  • Herbal tea: Mild, caffeine-free teas, like chamomile or peppermint, can soothe the stomach. Ensure they are not too hot or cold.

The BRAT and Low-Fiber Diet for Acute Diarrhea

For mild, short-term diarrhea, many oncologists and dietitians recommend a temporary switch to a bland, low-fiber diet, often based on the BRAT acronym. The goal is to give your irritated digestive system a rest.

BRAT diet components

  • Bananas: High in potassium, which helps replenish lost electrolytes. Bananas also contain pectin, a soluble fiber that adds bulk to stool.
  • White Rice: Easy to digest and low in fiber, white rice is a gentle source of carbohydrates for energy.
  • Applesauce: Cooked and peeled, applesauce is rich in pectin and easy on the gut. Avoid versions with added sugar.
  • White Toast: Simple, low-fiber white bread can help firm up stools. Avoid high-fiber whole-wheat bread initially.

Expanding beyond BRAT

Once symptoms begin to improve after a day or two, you can slowly add other bland, low-fat foods. This expansion is crucial, as the BRAT diet alone does not provide a complete range of nutrients.

Foods to Incorporate and Avoid During Immunotherapy Diarrhea

Transitioning back to a broader diet requires careful consideration. A low-fiber, low-fat approach is generally recommended while symptoms persist.

Low-fiber, low-fat foods to add

  • Lean protein: Baked or broiled chicken (skin removed), turkey, or fish are easy-to-digest protein sources essential for healing.
  • Peeled and well-cooked vegetables: Carrots, potatoes, and green beans are easier to digest when cooked until tender.
  • Cooked cereals: Cream of Wheat or Cream of Rice are bland and low in fiber.
  • Eggs: Scrambled or hard-boiled eggs provide protein without irritating the gut.
  • Smooth peanut butter: Provides protein and healthy fats but is less irritating than nuts with skins.
  • Yogurt with live cultures: Some patients tolerate yogurt well. The probiotics can help restore beneficial gut bacteria, but it may not be suitable if you develop temporary lactose intolerance.

Foods to avoid

  • High-fiber foods: Whole grains, nuts, seeds, legumes, and raw fruits and vegetables can irritate the bowel and should be avoided until symptoms resolve.
  • Lactose: Many patients experience temporary lactose intolerance. Avoid milk, soft cheeses, and ice cream. Hard cheeses and yogurt may be tolerated.
  • Fatty and greasy foods: Fried foods, rich sauces, and fatty meats can be difficult to digest and may worsen diarrhea.
  • Spicy and highly seasoned foods: Hot spices can irritate the stomach lining.
  • Caffeine and alcohol: Both can stimulate the bowels and worsen dehydration. Avoid coffee, caffeinated tea, and alcohol.
  • Gas-producing foods: Broccoli, cabbage, cauliflower, and beans can increase discomfort.
  • Sugar alcohols: Sorbitol and mannitol, found in many sugar-free products, have a laxative effect.

Dietary Comparison: Diarrhea vs. General Immunotherapy Nutrition

Feature During Acute Diarrhea (Short-Term) For General Immunotherapy (Long-Term)
Fiber Focus on low-fiber foods (white rice, white toast). Gradually increase fiber from whole grains, legumes, fruits, and vegetables to support gut health.
Hydration Emphasize electrolyte-rich fluids and broths to prevent dehydration. Maintain consistent hydration with water, juices, and other non-caffeinated fluids.
Fat Limit high-fat, greasy, and fried foods that can exacerbate symptoms. Incorporate healthy fats from sources like avocados, nuts, and olive oil.
Dairy Restrict or avoid dairy products due to potential temporary lactose intolerance. If tolerated, low-fat dairy can be part of a balanced diet for calcium and protein.
Meal Schedule Eat small, frequent meals throughout the day, as large meals can be harder to digest. Focus on three regular, balanced meals plus snacks as needed to maintain strength.

Conclusion

Managing diet is a critical and highly effective strategy for controlling immunotherapy-related diarrhea. The key is a step-wise approach: prioritize hydration and electrolyte replenishment, temporarily transition to a bland, low-fiber diet like BRAT, and then slowly reintroduce a broader range of easy-to-digest foods as symptoms subside. Every individual's tolerance can differ, so paying close attention to your body's response and keeping a food log can be invaluable. Always consult your oncology care team or a registered dietitian before making significant changes to your diet to ensure proper nutritional support throughout your treatment journey. Following these guidelines can help minimize discomfort and support your overall well-being during immunotherapy. For more information, the National Cancer Institute provides further resources on managing cancer treatment side effects.

Frequently Asked Questions

When diarrhea begins, focus on clear, low-fiber foods and drinks. The BRAT diet (bananas, white rice, applesauce, and white toast) is recommended. Prioritize oral rehydration solutions, clear broths, and plenty of water to replace lost electrolytes and fluids.

No, many patients experience temporary lactose intolerance due to intestinal irritation. It is best to avoid milk, soft cheeses, and ice cream. Yogurt and hard cheeses may be better tolerated by some, but it is often safer to avoid dairy entirely until symptoms improve.

During a diarrhea flare, you should temporarily limit or avoid high-fiber foods like whole grains, nuts, seeds, and raw fruits and vegetables. These can increase bowel activity and worsen symptoms. Once the diarrhea subsides, gradually reintroduce fiber as tolerated.

To prevent dehydration, drink plenty of clear, non-caffeinated, and non-alcoholic fluids. Excellent options include water, oral rehydration solutions, sports drinks (diluted), clear broths, and caffeine-free herbal tea.

No, it is best to avoid spicy and highly seasoned foods. These can irritate the digestive tract and exacerbate diarrhea. Stick to bland, mild-flavored foods to minimize gastrointestinal discomfort.

Focus on easily digestible, low-fat protein sources like baked or broiled chicken, turkey, fish, and eggs. Smooth peanut butter and cooked cereals can also provide calories and protein. Eating small, frequent meals can help ensure adequate intake when your appetite is low.

You should contact your healthcare provider if you have more than a few loose stools over your baseline, if your symptoms persist for more than a day or two, or if you notice blood or mucus in your stool. They may recommend medication or further evaluation to rule out more serious immune-related colitis.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.