Does Ginger Lower SHBG? A Comprehensive Look at Hormonal Effects

October 26, 2025 •

4 min read

According to a 2022 clinical trial, ginger supplementation was found to decrease sex hormone-binding globulin (SHBG) concentrations in women with polycystic ovary syndrome (PCOS). This finding has led to increased interest in the question: does ginger lower SHBG, and how might it affect broader hormonal health?

Quick Summary

A review of clinical and animal studies reveals that ginger can influence hormone levels, potentially decreasing SHBG, particularly in conditions like PCOS. The effect is linked to the spice's anti-inflammatory and antioxidant properties, which help regulate the endocrine system.

Key Points

Specific Population: A clinical trial found ginger lowered SHBG in women with Polycystic Ovary Syndrome (PCOS), but further research is needed for the general population.
Indirect Mechanism: Ginger's effect on SHBG is likely indirect, stemming from its ability to reduce inflammation, improve insulin sensitivity, and mitigate oxidative stress.
Not a Cure-All: While promising, ginger is not a definitive fix for high SHBG, and its effects can vary based on underlying health conditions.
Positive Effects on Testosterone: In males, animal and human studies indicate ginger can increase testosterone levels by enhancing LH and reducing oxidative stress.
Influences Other Hormones: In women, ginger has been shown to reduce FSH and LH in PCOS patients and potentially help balance estrogen levels during menopause.
Lifestyle is Key: Optimizing SHBG levels and overall hormonal health is best achieved through a holistic approach that includes diet, exercise, and stress management, not just a single supplement.

Understanding SHBG and Hormonal Balance

Sex hormone-binding globulin (SHBG) is a protein produced primarily in the liver that binds to androgens (like testosterone) and estrogens. By binding to these sex hormones, SHBG controls their bioavailability, meaning the amount of free, active hormone circulating in the body. High levels of SHBG can lead to lower levels of free testosterone, potentially causing symptoms such as low libido, fatigue, and decreased muscle and bone mass. Conversely, low SHBG levels are associated with conditions like obesity, type 2 diabetes, and high blood pressure. Balancing SHBG is crucial for maintaining overall hormonal health, and certain lifestyle and dietary factors, including ginger, may play a role.

Ginger's Potential Impact on SHBG

While research specifically on ginger and SHBG in healthy human populations is limited, a key study provides strong evidence in a specific context. A randomized double-blinded placebo-controlled trial published in Frontiers in Nutrition investigated the effects of ginger and other supplements on women with PCOS. The study revealed that ginger supplementation significantly decreased SHBG levels in this group, a hormonal effect not observed with the metformin treatment. This is particularly relevant as PCOS is often associated with insulin resistance and high androgen levels, which can also influence SHBG. The mechanism behind this observed decrease is not fully elucidated, but some researchers suggest it may relate to ginger's effects on insulin and inflammation.

Potential Mechanisms of Action

Ginger contains numerous bioactive compounds, including gingerols and shogaols, which contribute to its anti-inflammatory and antioxidant properties. These properties are theorized to impact hormone regulation in several ways:

Reducing Oxidative Stress: Chronic inflammation and oxidative stress can disrupt normal hormone production and function. Ginger's powerful antioxidant capacity can mitigate this damage, supporting the proper functioning of endocrine glands involved in hormone synthesis.
Improving Insulin Sensitivity: Insulin resistance is a common feature of conditions like PCOS, and high insulin levels are known to suppress SHBG production in the liver. By improving insulin sensitivity and helping to regulate blood sugar, ginger may indirectly help lower SHBG.
Modulating Cortisol: Chronic stress can elevate cortisol levels, which can disrupt the body's hormonal equilibrium. Ginger's adaptogenic properties may help modulate cortisol, contributing to a more balanced endocrine environment where SHBG is less likely to be dysregulated.
Supporting Liver Health: As the primary site of SHBG production, a healthy liver is essential for hormone balance. Ginger has protective effects on liver cells and helps manage metabolic function, which could influence SHBG regulation.

Ginger, Testosterone, and Female Hormones

Beyond SHBG, ginger has been shown to influence other hormones, including testosterone in males and estrogen and FSH/LH in females.

Ginger and Male Hormones

Multiple animal and human studies have linked ginger supplementation to increased testosterone levels in men, particularly in infertile individuals. The mechanisms include enhancing luteinizing hormone (LH) production, increasing testicular cholesterol levels, and reducing oxidative stress in the testes. The increase in testosterone is a key factor to consider alongside SHBG effects.

Ginger and Female Hormones

For women, ginger has demonstrated benefits for hormonal balance, especially concerning menopause and PCOS.


Aspect	Male Hormonal Effects	Female Hormonal Effects
Testosterone	Research, primarily from animal studies, shows ginger supplementation can increase testosterone levels, particularly under oxidative stress.	Ginger has been shown to help balance hormones, which can indirectly support testosterone production in females.
SHBG	While studies are limited, an indirect effect is possible given its impact on other hormones and metabolic factors.	Clinical trials in women with PCOS show ginger supplementation can decrease SHBG levels.
FSH & LH	Increases in LH and FSH levels have been observed, supporting healthy testicular function and testosterone synthesis.	Decreases in FSH and LH levels were noted in a study on women with PCOS.
PCOS	N/A	Found to decrease FSH, LH, and SHBG concentrations in women with PCOS, offering a potential alternative therapy.
Menopause	N/A	Promising benefits for managing menopausal symptoms by regulating estrogen levels and reducing FSH.

Important Considerations

While the research on ginger's hormonal effects is promising, especially in targeted populations, there are important points to remember:

Dosage and Formulation: The effective amount can vary significantly based on the preparation (raw, powdered, extract). Standardized extracts are often used in clinical trials for consistency.
Underlying Health Conditions: The impact of ginger on hormones may differ depending on the underlying health issue. For example, its effect on SHBG was specifically noted in women with PCOS and not necessarily the general population.
More Human Research is Needed: Much of the evidence, particularly concerning male testosterone and the precise mechanism behind SHBG reduction, comes from animal studies. More human clinical trials are required to confirm these findings and understand the full scope of effects.

Conclusion

Based on a 2022 clinical trial in women with polycystic ovary syndrome, ginger supplementation was shown to decrease SHBG concentrations. While this specific finding suggests a potential link, the general question of "does ginger lower SHBG?" remains complex. The mechanisms are likely tied to ginger's anti-inflammatory, antioxidant, and glucose-regulating properties, which can help rebalance the endocrine system, particularly in cases of oxidative stress or insulin resistance. Given that high SHBG is often linked to other health conditions, a holistic approach involving diet, exercise, and stress management is also critical for hormonal health. As with any supplement, consulting a healthcare provider is essential, especially when dealing with specific hormonal conditions.

Learn more about SHBG regulation and overall hormonal health here.

Frequently Asked Questions

While a clinical study showed ginger decreased SHBG levels in women with PCOS, it is not a universally proven solution for everyone. More research is needed in broader populations. For personalized advice, consult a healthcare provider.

Animal and some human studies, particularly in infertile men, have linked ginger to increased testosterone levels, possibly by reducing oxidative stress and increasing LH production. However, more clinical trials on the general male population are necessary.

In addition to reducing SHBG, ginger has been shown to lower FSH and LH levels in women with PCOS, which can help rebalance hormones. Its anti-inflammatory effects also address broader hormonal dysregulation.

Ginger is generally considered safe for consumption, but you should always consult a healthcare provider before using it as a supplement, especially if you have an existing health condition or are taking other medications. Mild side effects like heartburn can occur with higher amounts.

Effective amounts can vary widely in studies, depending on the preparation (raw, powdered, extract) and the individual. Standardized extracts are often used in clinical trials for consistent amounts.

While consuming ginger in food and tea is beneficial for overall health, studies on hormonal impacts, including SHBG, often use higher concentrations found in supplements. The effects of dietary intake on SHBG may be less pronounced.

Yes, other strategies include eating cruciferous vegetables, increasing protein intake, managing stress, and engaging in regular exercise. A holistic approach is often recommended for comprehensive hormonal health.