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Kwashiorkor: The Deficiency Disease is Caused Due to Lack of Proteins

4 min read

According to the World Health Organization, undernutrition, including severe protein deficiency, accounts for nearly half of all deaths in children under five globally. This highlights the devastating impact of a deficiency disease is caused due to lack of proteins, with Kwashiorkor being a particularly severe manifestation.

Quick Summary

Kwashiorkor is a severe form of protein-energy malnutrition primarily caused by protein deficiency. It leads to symptoms like fluid retention, stunted growth, and a distended abdomen. A related condition, Marasmus, involves an overall lack of calories and protein, causing severe wasting.

Key Points

  • Primary Disease: Kwashiorkor is the severe deficiency disease caused due to lack of proteins, resulting in fluid retention and swelling.

  • Kwashiorkor vs. Marasmus: While Kwashiorkor is primarily a protein deficiency, Marasmus is a deficiency of both protein and total calories, leading to severe emaciation.

  • Edema is a Key Symptom: The swelling characteristic of Kwashiorkor is caused by the body's inability to produce enough albumin to regulate fluid balance.

  • Risk Factors Extend Beyond Diet: Contributing factors include poverty, food insecurity, infections, and certain medical conditions that impair nutrient absorption.

  • Treatment Requires Medical Supervision: The re-introduction of nutrients must be gradual under medical care to prevent refeeding syndrome, a potentially life-threatening complication.

  • Prevention is Primarily Dietary: Ensuring a balanced diet with a variety of protein sources is the best prevention, especially important for children and pregnant women.

In This Article

Understanding Protein-Energy Malnutrition

Protein-Energy Malnutrition (PEM), also referred to as Protein-Energy Undernutrition (PEU), describes a range of conditions resulting from inadequate intake of calories, protein, or both. While most Americans get sufficient protein, PEM is a leading cause of death in children in many underdeveloped countries. The two most prominent forms of severe PEM are Kwashiorkor and Marasmus, each with distinct symptoms and underlying nutritional issues.

Kwashiorkor: The Primary Protein Deficiency Disease

The name Kwashiorkor originates from a Ghanaian language, meaning "the sickness the baby gets when the new baby comes". This refers to the situation where a weaning toddler is replaced at the mother's breast by a newborn and is fed a diet rich in carbohydrates but lacking in protein. The severe protein deficit leads to specific and tell-tale symptoms, most notably edema, or fluid retention.

Symptoms of Kwashiorkor include:

  • Edema: Swelling, particularly in the ankles, feet, hands, and face, is a classic sign. The body's inability to produce sufficient albumin, a protein that regulates fluid balance in the blood, causes this fluid leakage into tissues.
  • Distended Abdomen: A swollen, distended belly, known as ascites, is common due to fluid buildup in the abdominal cavity.
  • Skin and Hair Changes: The skin may become dry, flaky, or develop a rash, while hair can become dry, brittle, and lose its pigment.
  • Muscle Wasting: While swelling can mask it, there is significant loss of muscle mass.
  • Other Effects: Fatigue, irritability, apathy, and an enlarged, fatty liver are also common. A compromised immune system leads to increased susceptibility to infections.

Marasmus: Deficiency of Both Protein and Calories

Marasmus is another form of severe PEM, but it is characterized by an overall deficiency of all macronutrients—protein, carbohydrates, and fats. The term comes from the Greek word marasmos, meaning "withering". Unlike Kwashiorkor, Marasmus does not typically involve edema. Instead, its most striking feature is severe wasting and emaciation.

Symptoms of Marasmus include:

  • Severe Wasting: A shrunken, wasted appearance with a significant loss of muscle and fat stores.
  • Stunted Growth: Children with Marasmus exhibit severely stunted growth.
  • Loose Skin: Due to the loss of fat and muscle, the skin hangs loosely in folds.
  • Compromised Immunity: Similar to Kwashiorkor, a weakened immune system makes the individual more vulnerable to infections.
  • Lethargy and Apathy: The body's functions slow down significantly to conserve energy.

Kwashiorkor vs. Marasmus: A Comparative Look

Feature Kwashiorkor Marasmus
Primary Deficiency Severe protein deficiency, often with adequate calorie intake Overall deficiency of all macronutrients (protein, calories, fats)
Key Physical Sign Edema (swelling), particularly in the abdomen and limbs Severe muscle wasting and emaciation
Appearance Bloated stomach, puffy face and limbs, emaciated limbs Shrunken, starved appearance, prominent bones
Associated Factors Weaning from breast milk to low-protein, high-carbohydrate diet General starvation and inadequate nutrition from a very young age

Causes Beyond the Diet

While a lack of dietary protein is the direct cause of Kwashiorkor, several underlying factors contribute to malnutrition in general:

  • Poverty and Food Scarcity: Limited access to nutritious food is the most widespread cause, especially in regions experiencing famine or economic hardship.
  • Infections: Diseases like measles, gastroenteritis, or HIV can increase the body's need for nutrients or interfere with their absorption, worsening malnutrition.
  • Lack of Education: In some areas, a lack of nutritional knowledge can lead to poor dietary choices, such as feeding weaned children carbohydrate-heavy foods instead of protein-rich alternatives.
  • Medical Conditions: Certain illnesses, including malabsorption disorders like Crohn's disease or celiac disease, can prevent the body from absorbing enough protein, even if it is available in the diet.

Prevention and Treatment

Prevention is key to combating these devastating diseases. This involves ensuring a balanced diet that includes sufficient protein from a variety of sources. For vegetarians or vegans, combining different plant-based proteins can help provide all essential amino acids.

Treatment of severe malnutrition, especially in Kwashiorkor, must be carefully managed by medical professionals due to the risk of refeeding syndrome. The initial phase focuses on correcting electrolyte imbalances and dehydration before gradually introducing nutrient-dense foods to allow the body to stabilize and begin to recover. Long-term vitamin and mineral supplementation is often necessary. For more information on Kwashiorkor treatment, visit the Cleveland Clinic article on the subject: Kwashiorkor: Definition, Symptoms, Causes & Diagnosis.

Conclusion

The severe deficiency disease caused due to lack of proteins is Kwashiorkor, characterized by distinct edema and other systemic problems. It is a critical form of protein-energy malnutrition, though it should be distinguished from Marasmus, which involves a broader calorie and protein deficit. Understanding the symptoms, causes, and treatment options for these conditions is essential for promoting global health and addressing one of the most serious nutritional challenges affecting vulnerable populations, particularly children.

How Can You Prevent Protein Deficiency?

Preventing protein deficiency involves a multifaceted approach that includes consuming protein-rich foods, ensuring variety, and, where necessary, consulting with a healthcare provider. Simple strategies include incorporating lean meats, poultry, fish, eggs, and dairy, or plant-based sources like lentils, beans, nuts, and seeds into daily meals. It is also important to address any underlying medical conditions that might hinder nutrient absorption.

By taking proactive steps to ensure adequate protein intake, individuals can significantly reduce their risk of developing serious deficiency diseases like Kwashiorkor and Marasmus, fostering better overall health and well-being.

Frequently Asked Questions

The main deficiency disease primarily caused by a lack of proteins is Kwashiorkor. It is a severe form of protein-energy malnutrition characterized by fluid retention, particularly in the abdomen and limbs.

Common symptoms of Kwashiorkor include edema (swelling), a distended abdomen, changes in skin and hair pigment and texture, fatigue, and a weakened immune system.

Kwashiorkor is a result of a diet deficient in protein but often with enough calories, while Marasmus is caused by an overall deficiency of all macronutrients—protein, calories, and fat. Marasmus leads to severe wasting and emaciation, while Kwashiorkor causes swelling.

Children, particularly those around the age of weaning in regions with food insecurity, are most at risk. Pregnant women and the elderly can also be vulnerable.

PEM is a range of conditions resulting from inadequate intake of protein, calories, or both. It is also known as Protein-Energy Undernutrition (PEU) and includes severe forms like Kwashiorkor and Marasmus.

Diagnosis of Kwashiorkor often involves a physical examination to check for edema and an enlarged liver. Blood and urine tests can measure protein levels and assess overall nutritional status.

Yes, Kwashiorkor can be prevented by ensuring a balanced diet that includes enough high-quality protein from a variety of sources. In at-risk areas, nutritional education and access to fortified foods are crucial.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.