How Many Calories Are in a 16 Inch Pepperoni Pizza Slice?
                                
                                
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                                    5 min read                                
                            
                                According to nutritional data from one pizza retailer, a single slice from a 16-inch pepperoni pizza (cut into 8 slices) can contain around 390-480 calories or more. The number of calories in a 16 inch pepperoni pizza slice is not a fixed number and is heavily influenced by preparation, ingredients, and portion size.