How Many Calories Are in a 20 Inch Pizza? The Definitive Guide
                                
                                
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                                    4 min read                                
                            
                                A single slice from a 20-inch cheese pizza can contain upwards of 640 calories, but this is just one piece of the pie. The total number of calories in a 20-inch pizza is highly variable and depends on many factors, including the crust, cheese, and toppings.