Tag: Adora2a

Genetic variations in enzymes mean that how our bodies process caffeine can differ by up to 12 times from person to person. So, it's not just your imagination; some people are indeed highly sensitive to caffeine due to their unique genetic blueprint and other physiological factors.

Genetic factors play a significant role in determining an individual's response to caffeine, with a large variation in sensitivity found across the population. For some, a single cup of coffee can cause jitters and insomnia, while others can drink multiple cups with little effect. This difference is rooted in your unique genetic blueprint, which influences how your body processes and responds to this widely consumed stimulant.

According to a systematic review in the *Journal of Translational Medicine*, genetic factors influence individual caffeine responses, meaning caffeine is not effective for everyone. This variability explains why a morning coffee invigorates one person but causes another to feel anxious or jittery.

Genetics play a significant role in how our bodies process stimulants, leading to vast individual differences in caffeine response. This means for some, the question, 'can you be non-responsive to caffeine?' is a very real, scientifically-backed phenomenon, resulting in little to no stimulant effect from a normal dose.

Genetics can play a significant role in how your body responds to caffeine, with a single gene variation in the enzyme CYP1A2 determining if you are a "fast" or "slow" metabolizer of the stimulant. This means that for some, the buzz of a morning coffee is short-lived, while for others, that same dose can cause jitters and sleeplessness.