How Many Calories in a Slice of Homemade Birthday Cake?
                                
                                
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                                    5 min read                                
                            
                                On average, a standard-sized slice of homemade vanilla birthday cake with buttercream frosting can contain anywhere from 250 to 500 calories, or even more. The exact number of calories in a slice of homemade birthday cake depends heavily on the specific ingredients and portion size, making accurate calculations challenging.