Do you lose calories from getting blood drawn?
                                
                                
                                •
                                
                                
                        
                                    
                                    3 min read                                
                            
                                According to some estimates, your body may burn up to 650 calories replacing the red blood cells lost during a single whole blood donation. While this sounds significant, the answer to "Do you lose calories from getting blood drawn?" is more complex and less effective for weight loss than it seems. The energy expenditure occurs over an extended period, and the primary purpose is replenishment, not fat burning.