Can TPN Cause Abdominal Distension? Understanding the Link
                                
                                
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                                    4 min read                                
                            
                                A known complication of prolonged total parenteral nutrition (TPN) is intestinal distress, with epidemiological studies and clinical reviews confirming TPN-related gastrointestinal and hepatobiliary complications. This raises the question: **Can TPN cause abdominal distension**? The answer is yes, indirectly, through a series of physiological changes linked to this life-sustaining nutritional therapy.