How many calories in a vanilla cake with buttercream icing? A nutritional breakdown
                                
                                
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                                    4 min read                                
                            
                                A single slice of a standard, commercially prepared vanilla cake with buttercream icing can contain an average of 300 to 400 calories. But how many calories in a vanilla cake with buttercream icing depends heavily on the portion size, ingredients, and whether it's homemade or store-bought, making the numbers widely variable.