Tag: Caffeine insensitivity

Genetic factors play a significant role in how individuals respond to caffeine, with a liver enzyme variant, CYP1A2, determining how quickly you metabolize the stimulant. This variability is a key reason why some people wonder, "what does it mean if coffee doesn't work on you?", while others feel a strong buzz from a single cup.

Over 80% of US adults consume caffeine daily, yet many eventually question why they feel like caffeine doesn't affect me anymore. This common experience can be attributed to several factors, from building a physiological tolerance to genetic predispositions and accumulated sleep debt.

Genetics play a significant role in how our bodies process stimulants, leading to vast individual differences in caffeine response. This means for some, the question, 'can you be non-responsive to caffeine?' is a very real, scientifically-backed phenomenon, resulting in little to no stimulant effect from a normal dose.