How many calories are in a single slice of Domino's pizza?
                                
                                
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                                    4 min read                                
                            
                                According to Domino's official nutritional information, a single slice of their 14" Classic Hand-Tossed cheese pizza contains approximately 272 calories. This number can vary dramatically based on your choices of crust, toppings, and pizza size, influencing how many calories are in a single slice of Domino's pizza.