Tag: Cellular aging

According to scientific research, NAD+ levels decline by an estimated 10-80% as we age, contributing to many signs of cellular aging. When considering supplements, many people wonder, "Should I take NAD or collagen?" and the answer depends on which aspect of health you want to prioritize, as these two popular supplements work in fundamentally different ways.

Stem cells are the body's master cells, capable of renewing themselves and differentiating into many other cell types to repair tissue. Fortunately, there are many natural ways to enhance their vitality and production, offering a path to boosting your body's regenerative capacity and promoting overall well-being.

Genomic integrity is vital for human health and longevity, and studies show that diet, lifestyle, and environment significantly influence our DNA's stability and repair mechanisms. Our cells are equipped with powerful, natural defense systems for repairing DNA damage, but their efficiency can be optimized or hindered by our daily habits.

Scientific research indicates that oral NAD+ supplementation is largely ineffective due to the molecule's poor absorption and stability issues in the digestive tract. This surprising fact explains why the most common supplements on the market are not NAD+ itself, but rather its smaller, more bioavailable precursors.

Chronic overactivation of the cellular pathway known as mTOR is linked to aging and age-related diseases, including cancer and metabolic disorders. However, specific dietary interventions and natural compounds found in certain foods can help regulate this pathway, promoting cellular repair and longevity.

Mitochondria produce a significant amount of reactive oxygen species (ROS) during energy production, making them particularly vulnerable to oxidative stress. Glutathione is a critical antioxidant that protects these cellular powerhouses from damage, thereby helping to mitigate and reverse some cellular dysfunction.

Research has demonstrated that bioactive compounds in ginger, such as 6-gingerol and 6-shogaol, can trigger autophagy in cells by suppressing the mTOR signaling pathway. This discovery sheds light on how this traditional spice may promote cellular cleansing and support overall health and longevity.

According to a 2024 study in *Scientific Reports*, a higher dietary ketogenic ratio was associated with a significant reduction in all-cause mortality in a large cohort of U.S. adults, suggesting a link between metabolic shifts and longevity. This emerging research prompts a crucial question: does keto help with anti-aging by influencing the body's fundamental processes?

According to a 2025 Harvard clinical trial, daily vitamin D3 supplementation was shown to significantly reduce telomere shortening over four years, a key marker of biological aging. While both Vitamin D2 and D3 play roles in health, the cholecalciferol form demonstrates superior anti-aging benefits related to cellular protection and immune function.

Recent human studies suggest that certain fasting protocols, especially when combined with exercise, are associated with improved metabolic health markers and potentially longer telomeres. This has fueled scientific interest in whether fasting can influence this critical biomarker of cellular aging.