How to convert D-glucose to D-fructose? Methods and Mechanisms
                                
                                
                                •
                                
                                
                        
                                    
                                    6 min read                                
                            
                                High-fructose corn syrup, produced by converting glucose to fructose, became commercially widespread following the development of immobilized glucose isomerase in the 1970s. This biochemical process is a perfect example of isomerization, revealing the chemical manipulation behind many common sweeteners.