Tag: Citrulline vs arginine

In a 2006 study, researchers had to stop a trial on L-arginine's effects on heart attack survivors after six participants taking the supplement died. For this critical reason and many others, supplementing with arginine is not a good idea for a significant portion of the population, including those with pre-existing health conditions.

According to scientific studies, L-citrulline has shown gastroprotective effects and can help improve the gut barrier, suggesting potential benefits for a healthy stomach. However, some individuals may experience gastrointestinal upset from supplements, particularly at high doses.

Studies have repeatedly shown that supplementing with L-citrulline raises plasma L-arginine levels more effectively than taking L-arginine directly. This superior bioavailability is the primary reason why many individuals now opt to take citrulline instead of arginine for promoting nitric oxide production and enhancing athletic performance.