Tag: Citrullinemia

Citrulline, an amino acid vital for ammonia detoxification and nitric oxide production, can become deficient due to several complex factors. A deeper understanding of what causes citrulline deficiency is crucial, as it often points to an underlying metabolic issue, whether inherited or acquired.

L-citrulline deficiency typically signals an underlying genetic metabolic disorder, such as citrullinemia, impacting roughly 1 in 57,000 individuals globally. This condition disrupts detoxification, leading to ammonia buildup and a range of symptoms depending on the age of onset.