Tag: Dbp

Over 99% of circulating vitamin D and its metabolites are bound to carrier proteins in the bloodstream, with less than 1% circulating freely. To understand what does vitamin D bind to, we must examine its journey from synthesis to cellular action, involving several key molecules that facilitate its transport and function throughout the body.

A 2020 study found significant differences in 25-hydroxyvitamin D quantification between plasma and serum samples. This scientifically proven fact confirms that, indeed, there is vitamin D in plasma, where it circulates bound to special proteins, playing a critical role in the body's physiological processes.

Did you know that many vitamins rely on specialized protein carriers to travel through your bloodstream? This transport system is crucial for cellular delivery, and one key protein family, the alpha-2 globulins, plays a significant role. While several substances are carried in this protein fraction, the most definitive answer to which vitamin binds to alpha-2 globulin is Vitamin D.

Approximately 85-90% of vitamin D in the bloodstream is bound to a specific carrier, addressing the question of what protein carries vitamin D. This essential protein, known as vitamin D-binding protein (DBP), is critical for transporting vitamin D metabolites throughout the body to where they are needed.

Approximately 85–90% of all circulating vitamin D metabolites are bound to a specific carrier protein in the bloodstream. This vital transport protein, known as Vitamin D-Binding Protein (DBP), is responsible for carrying vitamin D throughout the body and controlling its availability to various tissues.

According to studies on twins and families, the heritability of vitamin D concentration can range widely, highlighting a significant genetic component that influences individual vitamin D levels. Understanding the specific genetic variants of vitamin D can help explain why some people are more susceptible to deficiency than others, even with similar sun exposure and dietary intake.