Tag: Dermatological symptoms

According to a 2020 review in the journal *Nutrients*, low vitamin B12 levels are associated with a greater risk of developing a range of neurological issues beyond the common fatigue and nerve tingling. This highlights the importance of recognizing what are the rare symptoms of B12 deficiency to ensure timely diagnosis and treatment, which can prevent more severe complications.

According to numerous clinical studies, knuckle hyperpigmentation—often mistaken for standard knuckle pads—is a well-documented early and reversible sign of vitamin B12 deficiency. While traditional knuckle pads are fibrous growths, the darkening pigmentation is a distinct nutritional manifestation that resolves with proper supplementation.

According to numerous medical studies, low levels of vitamin B12 can indeed cause a range of skin issues, including noticeable hyperpigmentation and vitiligo. This essential nutrient, also known as cobalamin, plays a critical role in cell regeneration and DNA synthesis, processes that are vital for maintaining healthy skin. When levels drop, the skin is often one of the first areas to show visible signs of distress.