Tag: Dihydrofolate reductase

Genetic variations can impact how the body processes folate, with approximately 60% of the US population having a common variant that affects this pathway. The conversion of supplemental folic acid into a usable form involves a crucial two-step enzymatic process.

According to the Centers for Disease Control and Prevention, the body uses folic acid quickly since it is water-soluble, requiring a regular daily intake through diet or supplements. However, simply consuming folic acid is not enough; a complex metabolic process involving specific enzymes and other B vitamins helps you break down folic acid and convert it into its active form for essential cellular functions.

Unlike humans, who must obtain folate from their diet, many microorganisms, such as bacteria and protozoa, must synthesize it internally, making their folate pathway a prime target for antimicrobial agents. This article explores what inhibits folate synthesis in various organisms and the mechanisms behind these crucial medical interventions.