Tag: First week diet

According to a study published in the journal *PLOS Biology*, when you first start restricting calories, your body's leptin levels (the hormone signaling fullness) decrease, while ghrelin (the hunger hormone) increases. This hormonal shift is one of several reasons why the first week of calorie deficit can feel like such a challenge, but is it actually the hardest part of the entire process?

Clinical trials show that gastrointestinal issues like nausea, diarrhea, and constipation are most common during the initial dose escalation period on semaglutide. Knowing what to eat the first week on semaglutide is therefore crucial for minimizing discomfort and maximizing your treatment's effectiveness as your body adjusts.

According to the Mayo Clinic, when you first cut calories, your body releases its glycogen stores for energy, leading to a rapid loss of water weight. This initial physiological shift is just one of many reasons why the first week of a diet is the hardest for many people, who must navigate intense hunger, cravings, and psychological resistance to new eating patterns.