Tag: Folic acid sensitivity

Genetic variations, particularly in the MTHFR gene, affect a significant portion of the population's ability to metabolize folic acid effectively. This can lead to a buildup of unmetabolized folic acid and a functional folate deficiency, impacting numerous bodily processes.

Case reports of hypersensitivity to synthetic folic acid have been documented since at least 1949, indicating that although extremely rare, it is indeed possible to be sensitive to folic acid. This sensitivity can manifest in various ways, from mild irritation to serious allergic reactions, distinguishing it from general intolerance or high-dose side effects.