Tag: Genetic obesity

The spontaneous discovery of an obese rat in 1961 by Lois and Theodore Zucker has led to one of the most widely used genetic models in metabolic research, known as the Zucker fatty rat model. This animal model is invaluable for investigating the complex mechanisms of obesity and related metabolic diseases.

Prader-Willi syndrome (PWS) is a rare genetic disorder caused by genetic abnormalities on chromosome 15, impacting appetite and metabolism. A highly structured and individualized nutrition therapy for Prader-Willi syndrome is essential to prevent life-threatening obesity and manage the constant feeling of hunger known as hyperphagia.