Tag: Gpr109a

A severe niacin deficiency, a condition known as pellagra, is characterized by significant digestive problems, including diarrhea and inflamed intestines. So, is niacin good for gut health? Research indicates it plays a multifaceted role in supporting a balanced microbiome, repairing intestinal barriers, and reducing inflammation.

Research has long investigated the multifaceted role of niacin in metabolism, confirming that at pharmacological doses, niacin can acutely inhibit lipolysis in adipose tissue. This suppression is achieved by activating a specific receptor on fat cells, leading to a temporary reduction in circulating free fatty acids.

Niacin, or vitamin B3, is converted into the crucial coenzyme NAD+ that powers over 400 enzymatic reactions in the body. However, at pharmacological doses, the mode of action of niacin extends far beyond simple vitamin function to encompass complex lipid-modulating and anti-inflammatory effects.