Tag: High dose thiamine

While the half-life of thiamine (vitamin B1) stored in the body's tissues is approximately 9 to 18 days, the half-life of circulating thiamine HCL in the bloodstream is much shorter, ranging from 1 to 12 hours depending on the dose. This variance highlights the difference between immediate availability and long-term bodily reserves of thiamine. The half-life is influenced by several factors, including the dosage administered and whether it was taken orally or intravenously.

According to the NHS, diarrhea is listed as a potential side effect of thiamine supplementation, particularly with higher doses. While the body typically excretes excess water-soluble B vitamins, high concentrations from supplements can sometimes irritate the digestive system, though it is usually mild and temporary.

Some research suggests an association between lower levels of thiamine (vitamin B1) and Parkinson's disease (PD), leading to investigations into supplementation. However, the question of how much B1 for Parkinson's is effective and safe remains complex, with no official consensus on usage.

While the daily recommended dietary allowance for thiamine (vitamin B1) is a mere 1.1–1.2 mg for adults, medical professionals may prescribe significantly higher amounts, such as 500 mg, for specific conditions. Understanding the safety and purpose behind high doses like 500 mg of thiamine is crucial for anyone considering supplementation beyond standard daily needs.

According to the National Academy of Medicine, no established toxic level of thiamine (vitamin B1) has been reported in the literature. As a water-soluble vitamin, any excess thiamine consumed orally is typically excreted through the urine, making toxicity from food sources or supplements highly unlikely.