Tag: High leucine

While leucine is a powerful amino acid known to be a key regulator of protein synthesis in muscle tissue, chronically high levels, especially from supplements, can trigger complex metabolic responses. Understanding what happens when leucine is high is crucial for anyone considering supplementation or monitoring their amino acid balance.

High plasma leucine levels, primarily associated with the metabolic disorder Maple Syrup Urine Disease (MSUD), can lead to severe neurological damage if not properly managed. The cornerstone of treatment for those who need to lower leucine levels is a specialized, life-long dietary restriction of branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine. Immediate medical intervention is crucial, particularly during metabolic crises, to prevent irreversible brain damage.