How Long Does It Take for L-Histidine to Work? A Timetable of Effects
                                
                                
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                                    5 min read                                
                            
                                In a 2022 study on mice, oral histidine intake improved working memory after prolonged sleep deprivation by replenishing brain histamine. But how long does it take for L-histidine to work for humans and for different conditions? The answer varies significantly depending on the health goal, dosage, and individual physiology.