Tag: Histidinemia

According to nutrition experts, a dietary histidine deficiency is rare in healthy individuals who consume adequate protein. What is the deficiency of histidine, and how does it manifest in the body? This guide explores the different ways a lack of this essential amino acid, both dietary and genetic, can impact your health.

According to Quest Diagnostics, the adult normal plasma range for histidine is 60–109 µmol/L. This semi-essential amino acid, vital for numerous bodily functions, is typically measured through blood tests as part of a comprehensive amino acid analysis.

According to the National Organization for Rare Disorders (NORD), the genetic condition histidinemia, which causes a buildup of histidine, is often asymptomatic. However, outside of this benign metabolic error, excess histidine—particularly from supplements—can cause side effects ranging from gastrointestinal upset to serious organ complications. Therefore, understanding what happens with too much histidine in the body is crucial for managing potential health risks.