Nutrition Diet: How many calories are in one large slice of pepperoni pizza?
                                
                                
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                                    3 min read                                
                            
                                According to nutritional data, a standard large slice of pepperoni pizza can contain anywhere from 250 to 350 calories, with factors like crust thickness and cheese quantity causing significant variation. Knowing **how many calories are in one large slice of pepperoni pizza** is crucial for anyone monitoring their intake as part of a balanced nutrition diet.