Tag: Hyperchloremic acidosis

Large volume infusions of normal saline, or 0.9% sodium chloride solution, can predictably cause hyperchloremic metabolic acidosis, a condition frequently observed in critically ill and surgical patients. This effect, often overlooked, is a critical consideration in modern fluid management.

While total parenteral nutrition (TPN) is a life-sustaining treatment, clinical studies have confirmed that it is associated with metabolic complications, including acidosis. The potential for TPN to cause acidosis, a condition of increased acidity in the blood and body tissues, is a significant concern for healthcare providers managing critically ill patients. This complex issue arises from various factors related to the TPN solution's composition and the patient's metabolic state.

Metabolic complications, including metabolic acidosis, are common and serious risks associated with total parenteral nutrition (TPN). These acid-base disturbances are often complex, resulting from the interaction of the TPN formula's composition, the patient's underlying disease state, and metabolic responses to refeeding.