Tag: Hypocretin

Discovered in the late 1990s, the hypothalamic neuropeptide orexin was initially named for its appetite-stimulating effects after early studies found that it increased food intake in rats. This discovery led to the question: does orexin increase appetite in all contexts, or is its function more complex?

A 2022 review published in the New Food Magazine highlights that while no foods contain the orexin neuropeptide directly, dietary components like non-essential amino acids can potently stimulate orexin-producing cells. This vital brain chemical, also known as hypocretin, plays a critical role in regulating wakefulness, energy balance, and appetite.

Contrary to a common misconception, no food directly contains the neuropeptide hypocretin (orexin), but specific nutrients and food types can significantly influence its production and function. This crucial neuropeptide helps regulate sleep-wake cycles, appetite, and energy balance, making a targeted diet an important part of supporting its role in your body.