Does Rutin Increase Nitric Oxide? Understanding the Context
                                
                                
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                                    4 min read                                
                            
                                Research published in the journal *Biomedicine & Pharmacotherapy* has shown that the flavonoid rutin can restore nitric oxide (NO) production in endothelial cells under high glucose stress. This finding, however, only tells one part of a complex story about whether rutin increase nitric oxide. The effect of this plant compound is highly dependent on the cellular environment and the specific type of nitric oxide synthase involved.