What Vitamin is Deficient in Knuckle Pads?
•
4 min read
According to numerous clinical studies, knuckle hyperpigmentation—often mistaken for standard knuckle pads—is a well-documented early and reversible sign of vitamin B12 deficiency. While traditional knuckle pads are fibrous growths, the darkening pigmentation is a distinct nutritional manifestation that resolves with proper supplementation.