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Tag: Knuckle hyperpigmentation

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What Vitamin is Deficient in Knuckle Pads?

4 min read
According to numerous clinical studies, knuckle hyperpigmentation—often mistaken for standard knuckle pads—is a well-documented early and reversible sign of vitamin B12 deficiency. While traditional knuckle pads are fibrous growths, the darkening pigmentation is a distinct nutritional manifestation that resolves with proper supplementation.