What Vitamin Deficiency Causes Knuckle Pads? A Comprehensive Guide
                                
                                
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                                    5 min read                                
                            
                                According to one study, knuckle hyperpigmentation has been observed in nearly one-fifth of patients with megaloblastic anemia, a condition often caused by low vitamin B12. This pigmentation, though sometimes mistaken for true knuckle pads, is a distinct symptom, helping to answer what vitamin deficiency causes knuckle pads.