Is Glucose Lipophilic or Lipophobic? The Definitive Guide
                                
                                
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                                    4 min read                                
                            
                                By its very nature, the cell membrane is a hydrophobic barrier, composed primarily of a lipid bilayer. This fact is critical to understanding the transport of molecules into and out of the cell, especially those like glucose. As a polar molecule with multiple hydroxyl (-OH) groups, glucose is lipophobic, meaning it is fat-rejecting, rather than lipophilic.