Tag: Metabolic reprogramming

Otto Warburg's observation in the 1920s first noted that cancer cells consume vast amounts of glucose, a phenomenon now central to understanding how to selectively starve cancer cells for therapeutic benefit. This metabolic weakness has become a critical area of focus for modern oncology.

Over the past two decades, research has revealed that cancer cells often display a marked dependence on the amino acid glutamine. This phenomenon, known as glutamine addiction, refers to the metabolic reprogramming that makes cancer cells heavily reliant on this nutrient for survival and proliferation, unlike normal cells.