Tag: Methylation imbalance

Genetic variations in the MTHFR gene can impair the body's ability to process folic acid, making methylfolate a necessary supplement for some, but taking too much methylfolate can trigger adverse side effects like severe anxiety and mood swings.

Functional vitamin B12 markers show no correlation with normal or even elevated serum B12 levels in many individuals, who nonetheless experience deficiency symptoms. This phenomenon, known as a paradoxical reaction to B12, describes a metabolic disconnect where the body cannot properly utilize the B12 it possesses. It highlights that simply having high serum B12 is not always enough for proper cellular function, making the diagnosis more complex than a simple blood test.