Tag: Mitophagy

As we age, cellular energy production and repair mechanisms often decline, contributing to the aging process. Emerging research suggests that key compounds like NAD and Urolithin A can support these vital functions. It is generally considered safe to combine these supplements, potentially leveraging their complementary effects on cellular health.

Research consistently shows that Urolithin A and NAD+ are not the same molecule, but they are both vital for cellular health, energy production, and the aging process. Understanding if Urolithin A is the same as NAD is crucial for anyone exploring supplements to support longevity and overall wellness.

While urolithin A is a powerful postbiotic linked to cellular health, only about 40% of people can produce it naturally from diet alone. Understanding your gut's ability to convert precursors is the first step in learning how to increase your urolithin naturally.

Research has documented that altered energy homeostasis and mitochondrial dysfunction is a hallmark of many chronic conditions. The question, 'Does fasting help your mitochondria?' addresses how intentional periods of food abstinence can reverse these issues and improve cellular health through potent metabolic adaptations.

Research indicates that fasting activates a cellular 'housekeeping' process called autophagy, which helps clear out damaged or inefficient components, including mitochondria. This metabolic state of low energy availability prompts cells to recycle and optimize their internal machinery.

Research indicates that a decline in mitochondrial function is a central hallmark of aging. This has prompted many to investigate whether Urolithin A increases mitochondria and improves cellular vitality as a potential anti-aging strategy.

Urolithin A is not found directly in any food; instead, this potent postbiotic is a product of metabolic activity in the gut microbiome, which ferments specific precursors found in certain fruits and nuts. Its creation is dependent on a healthy and active population of the right gut bacteria.

According to the U.S. Food and Drug Administration (FDA), Mitopure—a proprietary form of urolithin A—has achieved Generally Recognized as Safe (GRAS) status following a comprehensive review of its safety profile. This milestone provides a strong starting point for understanding its safety for regular consumption.

Urolithins, metabolites of ellagitannins from foods like pomegranates, have been shown to bind to estrogen receptors, exhibiting both estrogenic and antiestrogenic activities. This complex hormonal profile means that the answer to 'is urolithin estrogenic' depends on a variety of factors, including the specific tissue and the type of urolithin present.

As NAD+ levels naturally decline with age, many turn to supplements like Urolithin A and NAD+ precursors for support. The question for many is, can I take NAD and Urolithin A together for a more powerful, synergistic effect on mitochondrial function and overall vitality?