Understanding the Disadvantage of MSM Supplementation
                                
                                
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                                    4 min read                                
                            
                                While often marketed for its benefits in joint health and inflammation, up to 10% of users in some studies have reported mild side effects. The most notable disadvantage of MSM (methylsulfonylmethane) for many individuals is the potential for gastrointestinal upset, including symptoms such as nausea, diarrhea, and bloating.