Does Acetylcholine Affect Appetite? Unraveling the Cholinergic System's Role
                                
                                
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                                    3 min read                                
                            
                                In a 2016 study published in the journal *Nature*, researchers demonstrated that manipulating acetylcholine-producing neurons in mice dramatically altered their feeding behavior, confirming that acetylcholine does affect appetite. This dual role has since been the focus of intense research.