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Tag: N acetylglutamate

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What is the function of N-acetylglutamate in the urea cycle?

4 min read
In mammals, N-acetylglutamate (NAG) acts as an essential cofactor for the enzyme carbamoyl phosphate synthetase I (CPS1), which controls the initial, rate-limiting step of the urea cycle. This process is crucial for preventing the buildup of toxic ammonia, a waste product of protein metabolism.