Can people be naturally tolerant to caffeine?
                                
                                
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                                    5 min read                                
                            
                                According to genetic studies, approximately half the population carries a gene variant that causes them to metabolize caffeine more slowly, profoundly affecting their tolerance. So, can people be naturally tolerant to caffeine? The answer lies in your individual genetic makeup, which dictates how your body processes and responds to the stimulant from the very first sip.