Tag: Neuromuscular junction

According to the National Institutes of Health, skeletal muscle makes up about 40% of the human body's weight. At a cellular level, the essential process that plays a key role in the contraction of muscles relies on a precise choreography of molecules, primarily involving calcium ions and the energy-carrying molecule ATP.

In 1954, landmark research demonstrated that increasing extracellular magnesium concentration directly reduced the amount of acetylcholine released by nerve terminals by 10-40%. This established a fundamental physiological principle: magnesium acts as a natural inhibitor of acetylcholine release, profoundly influencing nerve-to-muscle communication.