How Many Calories Are in One Puff of Nicotine? Separating Fact from Vapor
                                
                                
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                                    5 min read                                
                            
                                According to several sources, a single milliliter of e-liquid contains approximately 4 to 5 calories, meaning that one puff delivers a nearly immeasurable, sub-one-calorie amount. This guide explains why the calories in a nicotine puff are not a dietary concern and separates fact from fiction regarding vaping and weight.