Tag: Nlrp3 inflammasome

Chronic inflammation is a leading cause behind many serious diseases, including heart disease, diabetes, and cancer. A growing body of research suggests that fasting, or restricting food intake, may serve as a potent tool to help regulate the body's inflammatory response.

Studies have shown that ketone bodies, particularly beta-hydroxybutyrate (BHB), have direct anti-inflammatory effects. Ketones, produced during fasting or carbohydrate restriction, can act as signaling molecules that suppress inflammatory pathways in the body, offering a potential therapeutic strategy for various chronic conditions.

A 2024 meta-analysis revealed that a ketogenic diet significantly reduced inflammatory biomarkers like C-reactive protein (CRP) in overweight and obese individuals, challenging the notion that ketones are inherently inflammatory. This finding points to a more nuanced relationship between ketosis and the body's inflammatory response.

According to numerous studies, the main ketone body, beta-hydroxybutyrate (BHB), has been shown to exhibit a predominantly anti-inflammatory response. This finding directly contradicts the misconception that ketones cause inflammation, revealing instead that they possess anti-inflammatory properties, particularly in specific metabolic contexts. The relationship between ketones and inflammation is complex and dependent on various factors, including the type of ketone, the source (endogenous or exogenous), and the overall dietary pattern.

Recent research has identified a potential new mechanism by which fasting may help reduce inflammation. This growing body of evidence has led many to question: do fasting lower inflammation? The answer is complex, hinging significantly on the fasting type and its duration.

According to a 2024 meta-analysis published in *Nutrients*, the ketogenic diet significantly lowered the inflammatory marker C-reactive protein in overweight individuals. This evidence supports the popular question: is ketosis anti-inflammatory?