Tag: Orexin

According to research, high sugar intake can suppress orexin, a neuropeptide that regulates wakefulness. For many, the anticipated energy boost from sugary treats never comes, replaced instead by a feeling of lethargy that leaves them drained. This explains why does sugar make me tired instead of hyper?

According to a study published in the journal *Sleep*, consumption of high-carbohydrate meals can increase daytime sleepiness, and this phenomenon explains why you feel sleepy after eating a cookie. This common sensation is a result of your body's intricate metabolic and hormonal response to a rapid sugar intake.

Recent research confirms that hypothalamic orexin neurons are highly sensitive to dietary macronutrients, such as glucose and amino acids, with diet profoundly influencing the activity of this crucial brain peptide. A disruption in this system can have significant consequences for sleep, metabolism, and appetite regulation.

Orexin, a neuropeptide critical for maintaining alertness, can be influenced by diet and specific compounds. While no supplement offers a direct increase of orexin in the way a neurotransmitter medication would, certain nutritional and botanical ingredients, alongside lifestyle factors, can support its signaling pathways. Understanding what supplements increase orexin levels involves exploring indirect support rather than direct synthesis.

Discovered in the late 1990s, the hypothalamic neuropeptide orexin was initially named for its appetite-stimulating effects after early studies found that it increased food intake in rats. This discovery led to the question: does orexin increase appetite in all contexts, or is its function more complex?

According to a 2019 study, consuming sugar can lead to increased fatigue and decreased alertness just one hour later. If you've ever asked, "Why do I get tired after drinking sugar?", the answer lies in a complex interplay of hormonal and biochemical responses within your body. This article explains the science behind that familiar feeling of sluggishness and provides actionable steps to maintain stable energy levels.

Initially identified in 1998 as a hypothalamic peptide that acutely stimulates food intake, orexin was named after the Greek word 'orexis' for appetite. However, the relationship between orexin and hunger is far more complex than simple stimulation, involving broader regulation of energy balance and arousal.

Orexin, a neuropeptide produced in the hypothalamus, plays a critical role in regulating wakefulness, arousal, and appetite. However, no foods contain orexin directly; rather, certain nutrients and eating patterns influence its production and sensitivity. This raises the question: **What foods are high in orexin**-supporting nutrients and beneficial for your overall health?

Recent studies, particularly in pediatric patients, have shown a significant statistical association between low serum vitamin B12 levels and the development of narcolepsy. This discovery prompts many to question the definitive role of diet and ask, **which vitamin deficiency causes narcolepsy?**.

Contrary to a common misconception, no food directly contains the neuropeptide hypocretin (orexin), but specific nutrients and food types can significantly influence its production and function. This crucial neuropeptide helps regulate sleep-wake cycles, appetite, and energy balance, making a targeted diet an important part of supporting its role in your body.